Polycythaemia vera — RCPSC IM MCQ
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Correct answer: B — Plan antiresorptive transition with timed denosumab discontinuation
Explanation lettering: E = shown as A · C = shown as B · D = shown as C · B = shown as D · A = shown as E
C is correct: denosumab discontinuation can cause rapid bone loss and rebound vertebral fractures, so transition therapy should be planned. D, E, A and B fail to manage this risk.
Reference: Osteoporosis Canada, 2023 guideline: https://osteoporosis.ca/2023-clinical-practice-guideline/