A patient has microangiopathic hemolytic anemia, thrombocytopenia and severe AKI after a diarrheal illness. ADAMTS13 activity is normal and stool

Question

A patient has microangiopathic hemolytic anemia, thrombocytopenia and severe AKI after a diarrheal illness. ADAMTS13 activity is normal and stool testing identifies Shiga toxin. What supportive management principle is most appropriate?

Accepted Answer

Provide renal and fluid support; avoid antibiotics and antimotility agents

Answer

Start plasma exchange because every thrombotic microangiopathy is TTP

Answer

Start broad-spectrum antibiotics to eradicate Shiga toxin

Answer

Use high-dose corticosteroids as disease-modifying treatment

Answer

Give platelet transfusions to normalize the count before renal replacement therapy

Primary aldosteronism — RCPSC IM MCQ

A patient has microangiopathic hemolytic anemia, thrombocytopenia and severe AKI after a diarrheal illness. ADAMTS13 activity is normal and stool testing identifies Shiga toxin. What supportive management principle is most appropriate?