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Serotonin syndrome — RCPSC EM MCQ

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ModerateToxicologySerotonin syndromeRCPSC EM

A 52-year-old man taking citalopram and tramadol presents with agitation, diaphoresis and diarrhoea. Temperature is 39.1°C, HR 138, BP 168/92, and exam shows inducible clonus and hyperreflexia in the legs. What is the most likely diagnosis?

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Correct answer: C — Serotonin syndrome

Serotonergic medication exposure with autonomic instability, diarrhoea, clonus and hyperreflexia is serotonin syndrome.

Reference: Poison centre toxicology guidance; Goldfrank-style ED toxicology principles