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Central precocious puberty — RACP Paediatrics MCQ

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HardEndocrinology and growthCentral precocious pubertyRACP Paediatrics

A 6-year-old girl has progressive breast development, growth acceleration and vaginal discharge. Bone age is advanced by two years and basal LH is pubertal. Neurological examination is normal. What is the most appropriate investigation?

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Correct answer: A — MRI brain and pituitary with paediatric endocrine referral

Progressive puberty before age 8 with pubertal LH suggests central precocious puberty. MRI is recommended particularly in younger children to assess for central lesions, alongside endocrine review. Growth acceleration and advanced bone age distinguish true puberty from isolated premature thelarche.

Reference: RACP Knowledge Guides; Australian paediatric endocrine guidance