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Suspected primary biliary cholangitis — PARA MCQ

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ModerateGeneral Medicine - HepatologySuspected primary biliary cholangitisPARA

A 72-year-old woman has chronic itch, fatigue and cholestatic liver tests. Ultrasound shows no biliary obstruction. What is the most appropriate investigation?

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Correct answer: B — Antimitochondrial antibody testing

Cholestatic liver tests and pruritus with no obstruction should prompt autoimmune liver screening; antimitochondrial antibodies support primary biliary cholangitis.

Reference: BSG/UK-PBC guideline; NICE CKS: Pruritus