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Pernicious anaemia — PARA MCQ

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ModerateGeneral Medicine - HaematologyPernicious anaemiaPARA

A 70-year-old woman has macrocytic anaemia, glossitis and paraesthesia in both feet. B12 is low and intrinsic factor antibodies are positive. What is the most appropriate management?

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Correct answer: B — Hydroxocobalamin replacement according to BNF regimen

B12 deficiency with neurological symptoms and intrinsic factor antibodies suggests pernicious anaemia. Parenteral hydroxocobalamin replacement is indicated.

Reference: NICE CKS: Anaemia - B12 and folate deficiency; BNF