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Hyperosmolar hyperglycaemic state — PARA MCQ

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HardGeneral Medicine - EndocrinologyHyperosmolar hyperglycaemic statePARA

A 72-year-old man with type 2 diabetes is drowsy after 5 days of thirst and polyuria. Glucose is 46 mmol/L, osmolality is 338 mOsm/kg, ketones are 0.3 mmol/L and venous pH is 7.36. What is the most likely cause?

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Correct answer: DRelative insulin deficiency causing severe osmotic dehydration

Marked hyperglycaemia, high osmolality, minimal ketones and normal pH indicate HHS. It reflects relative insulin deficiency with profound osmotic diuresis and dehydration rather than ketoacidosis.

Reference: Joint British Diabetes Societies guideline: Hyperosmolar hyperglycaemic state; NICE NG28