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Polycystic ovary syndrome — MCCQE Part 1 MCQ

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ModerateInfertilityPolycystic ovary syndromeMCCQE Part 1

A 29-year-old nulliparous woman has irregular menses, acne, hirsutism, and difficulty conceiving. BMI is 33 kg/m2. TSH and prolactin are normal; total testosterone is mildly elevated. What is the most likely diagnosis?

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Correct answer: A — Polycystic ovary syndrome

Oligo-ovulation, clinical hyperandrogenism, obesity, and mildly elevated testosterone with normal TSH and prolactin fit polycystic ovary syndrome. Primary ovarian insufficiency usually has elevated FSH and hypoestrogenic symptoms. Prolactinoma would elevate prolactin. An androgen-secreting tumour usually causes rapid virilisation and markedly elevated androgens.

Reference: SOGC polycystic ovary syndrome guidance