Desflurane rapid wash-in — FRCA Primary MCQ

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EasyPharmacologyDesflurane rapid wash-inFRCA Primary

During a short day-case procedure, the anaesthetist wants an inhalational agent that permits rapid adjustment of anaesthetic depth. Which property of desflurane is most relevant?

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Correct answer: D — Low blood-gas solubility

Desflurane has very low blood-gas solubility, so alveolar concentration approaches inspired concentration quickly. Oil-gas solubility relates more closely to potency, not speed of wash-in. Desflurane undergoes little metabolism, but this is not the main determinant of rapid titratability. Its low potency and high vapour pressure explain the need for a specialised vaporiser.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; RCoA Primary FRCA Syllabus