Sugammadex reversal — FRCA Primary MCQ

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ModeratePharmacologySugammadex reversalFRCA Primary

A patient with myasthenia gravis receives rocuronium during an emergency laparoscopy and has residual neuromuscular blockade at the end. Which drug reverses this by encapsulating the neuromuscular blocker in plasma?

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Correct answer: C — Sugammadex

Sugammadex is a modified γ-cyclodextrin that encapsulates aminosteroid neuromuscular blockers, especially rocuronium and vecuronium. Neostigmine increases acetylcholine at the neuromuscular junction but does not remove the blocker from plasma. Glycopyrronium treats muscarinic effects of anticholinesterases, and dantrolene treats malignant hyperthermia. Quantitative monitoring remains essential because reversal dose depends on block depth.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care