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Suspected ovarian cancer — DRCOG MCQ

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HardGynaecological OncologySuspected ovarian cancerDRCOG

A 58-year-old with persistent early satiety and abdominal distension has CA125 82 IU/mL. Pelvic and abdominal ultrasound is reported as normal. Symptoms continue after two weeks. Which plan is most appropriate?

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Correct answer: DInvestigate other causes, safety-net symptoms and review her early in primary care

The best answer is “Investigate other causes, safety-net symptoms and review her early in primary care”. A normal ultrasound does not end assessment when concerning symptoms persist. NICE advises evaluating other causes, providing explicit safety-netting and arranging review; persistent or worsening symptoms require further investigation or referral. Neither an isolated CA125 elevation nor symptoms alone justify definitive surgery or treatment without diagnosis.

Reference: NICE CG122: Ovarian cancer recognition and initial management: https://www.nice.org.uk/guidance/cg122/chapter/recommendations