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Vinyl chloride and liver angiosarcoma — DOccMed MCQ

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HardOccupational CancerVinyl chloride and liver angiosarcomaDOccMed

A 58-year-old former PVC polymerisation worker develops right upper quadrant pain, weight loss and abnormal liver imaging suggesting angiosarcoma. He worked in autoclave cleaning with historical vinyl chloride monomer exposure. What is the most likely occupational diagnosis?

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Correct answer: C — Hepatic angiosarcoma associated with vinyl chloride monomer

Vinyl chloride monomer is a recognised occupational cause of hepatic angiosarcoma, particularly in PVC production. The job history and tumour type are highly specific. Alcohol may cause liver disease but does not explain this rare tumour association. Benzene is linked to haematological malignancy rather than hepatic angiosarcoma.

Reference: IIDB prescribed diseases guidance; HSE carcinogens guidance