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Laboratory animal allergy — DOccMed MCQ

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HardInfection Control and Biological HazardsLaboratory animal allergyDOccMed

A research technician develops sneezing, itchy eyes and wheeze when cleaning mouse cages. Symptoms improve during two weeks of data-analysis duties; specific IgE to mouse urine proteins is positive. What is the most likely occupational diagnosis?

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Correct answer: E — Laboratory animal allergy with occupational asthma risk

Mouse urinary proteins are potent occupational sensitisers. Rhinitis and wheeze during cage cleaning with positive specific IgE strongly suggest laboratory animal allergy and asthma risk. Improvement away from animal rooms supports occupational causation. Irritant disinfectant exposure may contribute but does not explain specific IgE sensitisation.

Reference: HSE Laboratory animal allergy guidance; COSHH Regulations