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Post-ROSC hypoxaemia — DipIMC MCQ

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ModerateResuscitationPost-ROSC hypoxaemiaDipIMC

A 70-year-old man has ROSC after out-of-hospital VF arrest. He remains unconscious, has SpO2 100% on high-flow oxygen, systolic blood pressure 92 mmHg and end-tidal CO2 7.2 kPa during assisted ventilation. What is the most appropriate immediate action?

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Correct answer: DVentilate to normocapnia and titrate oxygen to SpO2 94-98%

Post-ROSC care aims for adequate oxygenation without hyperoxaemia and ventilation toward normocapnia. Persistent SpO2 100% on high-flow oxygen suggests oxygen should be titrated if reliable monitoring is available. Hyperventilation can reduce cerebral blood flow and worsen neurological injury.

Reference: Resuscitation Council UK Post-resuscitation care 2025