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Opioid-associated respiratory arrest — DipIMC MCQ

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ModerateResuscitationOpioid-associated respiratory arrestDipIMC

A 31-year-old man is found in a hostel with pinpoint pupils, respiratory rate 4/min, SpO2 78% and a palpable carotid pulse. Bag-mask ventilation with oxygen improves SpO2 to 92%; IV access is present. What is the most appropriate drug/dose?

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Correct answer: ANaloxone 400 micrograms IV titrated to adequate ventilation

The immediate threat is opioid-induced hypoventilation, so airway support and titrated naloxone to restore ventilation are appropriate. Large boluses may precipitate agitation, vomiting and withdrawal without improving safety. Adrenaline is for cardiac arrest or anaphylaxis, not isolated opioid toxicity with a pulse.

Reference: JRCALC Guidelines; Resuscitation Council UK First Aid 2025