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RhD alloimmunisation prevention — MCCQE Part 1 MCQ

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ModeratePregnancyRhD alloimmunisation preventionMCCQE Part 1

A 29-year-old RhD-negative pregnant woman at 28 weeks has a negative antibody screen and no bleeding during pregnancy. Her partner's Rh status is unknown. What is the most appropriate screening/prevention?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Administer routine antenatal Rh immune globulin according to local programme

Unsensitised RhD-negative pregnant patients should receive antenatal Rh immune globulin at around 28 weeks according to provincial practice, with postpartum prophylaxis if the infant is RhD-positive. A negative antibody screen means she is a candidate for prophylaxis, not that it is unnecessary. Amniocentesis is not routine first-line prevention.

Reference: SOGC Rh alloimmunisation guidance