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Neonatal cholestasis — ABFM Board MCQ

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HardPediatrics and adolescent medicineNeonatal cholestasisABFM Board

A 2-week-old breastfed infant has persistent jaundice. He is feeding well and gaining weight. Total bilirubin is 9.5 mg/dL with direct bilirubin 3.1 mg/dL; stools are pale. Which of the following is the most appropriate next step?

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Correct answer: D — Urgent evaluation for cholestasis and biliary atresia

Conjugated hyperbilirubinemia and pale stools in an infant are pathologic and require urgent evaluation for cholestasis, including biliary atresia. Early diagnosis improves surgical outcomes.

Reference: NASPGHAN Cholestatic Jaundice Guideline