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Celiac disease — ABFM Board MCQ

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HardGI/HepatologyCeliac diseaseABFM Board

A 36-year-old woman has watery diarrhea for 8 months, weight loss, and iron-deficiency anemia. Tissue transglutaminase IgA is positive and total IgA is normal. Which of the following is the most likely diagnosis?

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Correct answer: C — Celiac disease

Chronic diarrhea, weight loss, iron deficiency, and positive tissue transglutaminase IgA with normal total IgA support celiac disease. Diagnosis is typically confirmed with duodenal biopsy before a gluten-free diet.

Reference: ACG Celiac Disease Guideline