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Polycystic ovary syndrome — ABFM Board MCQ

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ModerateWomen's health/OB/GYNPolycystic ovary syndromeABFM Board

A 31-year-old woman has irregular menses, acne, and hirsutism. BMI is 34 kg/m². Pregnancy test is negative, TSH and prolactin are normal, and total testosterone is mildly elevated. Which of the following is the most likely diagnosis?

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Correct answer: A — Polycystic ovary syndrome

Oligo-ovulation plus clinical or biochemical hyperandrogenism after exclusion of pregnancy, thyroid disease, and hyperprolactinemia is consistent with polycystic ovary syndrome. Marked virilization or very high androgen levels would suggest a tumor.

Reference: Endocrine Society PCOS Guideline