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Microprolactinoma with infertility — USMLE Step 3 MCQ

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HardOB/GYNMicroprolactinoma with infertilityUSMLE Step 3

A 30-year-old woman has secondary amenorrhea for 8 months and galactorrhea. Pregnancy test is negative. Prolactin is 118 ng/mL, TSH is normal, and MRI shows a 6-mm pituitary lesion. She wants pregnancy in the next year. Which of the following is the most appropriate next step in management?

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Correct answer: DDopamine agonist therapy

A microprolactinoma causing amenorrhea and infertility is treated first-line with a dopamine agonist such as cabergoline or bromocriptine, which lowers prolactin and restores ovulation.

Reference: Endocrine Society Hyperprolactinemia Guideline