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Kallmann syndrome — SCE Endocrinology MCQ

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ModerateReproductive endocrinologyKallmann syndromeSCE Endocrinology

A 17-year-old has delayed puberty and absent sense of smell. He is tall with eunuchoid proportions; testes are 3 ml bilaterally. Testosterone is low with low LH and FSH; prolactin is normal. What is the most likely diagnosis?

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Correct answer: D — Kallmann syndrome

Kallmann syndrome is best because hypogonadotrophic hypogonadism with anosmia is typical of Kallmann syndrome. The alternatives are less appropriate because Klinefelter and post-orchitis failure raise gonadotrophins; constitutional delay lacks anosmia; androgen insensitivity does not fit the male delayed puberty phenotype. The SCE teaching point is to integrate the clinical pattern, biochemistry and context rather than treating an isolated result.

Reference: Endocrine Society hypogonadism guidance