skip to main content

Paget's disease of bone — SCE Endocrinology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCalcium/BonePaget's disease of boneSCE Endocrinology

A 74-year-old man has skull enlargement, deafness and hip pain. ALP is 680 IU/L with normal calcium, phosphate, PTH and liver enzymes. Pelvic radiograph shows cortical thickening and coarse trabeculae. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Paget's disease of bone

Isolated raised ALP with typical radiographic bone expansion and cortical thickening indicates Paget's disease. Osteomalacia more often has low vitamin D and biochemical mineral abnormalities. The pearl is that bisphosphonate treatment is used for active symptomatic disease.

Reference: Endocrine Society Paget's disease guideline, BNF