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Glucocorticoid-induced osteoporosis — SCE Endocrinology MCQ

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ModerateCalcium/BoneGlucocorticoid-induced osteoporosisSCE Endocrinology

A 69-year-old woman with polymyalgia rheumatica starts prednisolone 20 mg daily for a planned 9 months. She had a wrist fracture after a fall last year. Calcium and vitamin D are adequate and eGFR is 70 ml/min/1.73 m². What is the most appropriate management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EAssess fracture risk and start bone-protective bisphosphonate therapy

Glucocorticoids rapidly increase fracture risk, especially after a fragility fracture, so fracture-risk assessment and bone protection are appropriate. Waiting until steroids finish misses the period of highest early risk. The pearl is that steroid dose and previous fracture drive urgency.

Reference: NICE CG146, NOGG osteoporosis guideline