Insulinoma — SCE Endocrinology MCQ
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Correct answer: C — Insulinoma as the diagnosis
Whipple's triad with inappropriately elevated insulin and C-peptide during hypoglycaemia and negative sulfonylurea screen indicates endogenous hyperinsulinism from insulinoma. Factitious insulin would suppress C-peptide. The pearl is that biochemical proof during hypoglycaemia precedes localisation.
Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/diabetes-and-other-endocrinal-nutritional-and-metabolic-conditions