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Insulinoma — SCE Endocrinology MCQ

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HardMEN/NET/MiscellaneousInsulinomaSCE Endocrinology

A 45-year-old man has recurrent fasting confusion relieved by eating. During a supervised fast, glucose is 2.1 mmol/L with insulin 12 mU/L, C-peptide 820 pmol/L and sulfonylurea screen negative. CT pancreas shows a 1.2 cm lesion in the tail. What is the most likely diagnosis?

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Correct answer: CInsulinoma as the diagnosis

Whipple's triad with inappropriately elevated insulin and C-peptide during hypoglycaemia and negative sulfonylurea screen indicates endogenous hyperinsulinism from insulinoma. Factitious insulin would suppress C-peptide. The pearl is that biochemical proof during hypoglycaemia precedes localisation.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/diabetes-and-other-endocrinal-nutritional-and-metabolic-conditions