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Hyperosmolar hyperglycemic state — ABEM Board MCQ

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ModerateRenal/Metabolic emergenciesHyperosmolar hyperglycemic stateABEM Board

A 49-year-old man arrives as ESI 2 with confusion, vomiting, and deep respirations. Glucose is 780 mg/dL, pH 7.34, bicarbonate 19 mEq/L, serum osmolality 352 mOsm/kg, and urine ketones are trace. Which of the following is the most likely diagnosis?

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Correct answer: DHyperosmolar hyperglycemic state

Profound hyperglycemia, high osmolality, minimal ketosis, and near-normal pH support HHS.

Reference: ADA standards of care; Endocrine Society hyperglycemic crisis guidance