Myxoedema coma with hyponatraemia — SCE Acute Medicine MCQ
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Correct answer: D — Hydrocortisone 100 mg intramuscularly now, then 200 mg over each 24 hours
Explanation lettering: D = shown as C · E = shown as D · C = shown as E
E is correct. Suspected adrenal crisis is treated immediately with hydrocortisone 100 mg IV or IM, followed by 200 mg/24 hours, plus rapid rehydration and correction of hypoglycaemia. Treatment must not await cortisol results. Fludrocortisone alone cannot replace the required glucocorticoid stress dose; mineralocorticoid replacement becomes relevant again when hydrocortisone is tapered below stress doses. The oral low-dose regimens are inadequate in shock and vomiting.
Reference: Society for Endocrinology: adrenal crisis: https://www.endocrinology.org/adrenal-crisis