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Myxoedema coma with hyponatraemia — SCE Acute Medicine MCQ

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HardDiabetes and endocrine medicineMyxoedema coma with hyponatraemiaSCE Acute Medicine

A woman with autoimmune adrenal insufficiency has vomiting, hypotension, sodium 121 mmol/L, potassium 6.0 mmol/L and glucose 3.0 mmol/L. Intravenous access is delayed. Which immediate glucocorticoid plan is correct while isotonic fluid and glucose are arranged?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DHydrocortisone 100 mg intramuscularly now, then 200 mg over each 24 hours

Explanation lettering: D = shown as C · E = shown as D · C = shown as E

E is correct. Suspected adrenal crisis is treated immediately with hydrocortisone 100 mg IV or IM, followed by 200 mg/24 hours, plus rapid rehydration and correction of hypoglycaemia. Treatment must not await cortisol results. Fludrocortisone alone cannot replace the required glucocorticoid stress dose; mineralocorticoid replacement becomes relevant again when hydrocortisone is tapered below stress doses. The oral low-dose regimens are inadequate in shock and vomiting.

Reference: Society for Endocrinology: adrenal crisis: https://www.endocrinology.org/adrenal-crisis