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Serotonin toxicity — RCPSC EM MCQ

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ModerateToxicologySerotonin toxicityRCPSC EM

CTAS 2. A 23-year-old taking sertraline starts linezolid and presents with agitation, diaphoresis, diarrhoea, and tremor. Temp is 39.2°C, HR 134, and exam shows inducible ankle clonus and hyperreflexia. What is the most likely diagnosis?

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Correct answer: A — Serotonin toxicity

Recent serotonergic interaction with hyperthermia, diarrhoea, clonus, and hyperreflexia is characteristic of serotonin toxicity.

Reference: Ontario Poison Centre serotonin toxicity guidance; Goldfrank's Toxicologic Emergencies