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Serotonin syndrome — RCPSC EM MCQ

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ModerateToxicologySerotonin syndromeRCPSC EM

CTAS 2: A 28-year-old started linezolid while taking sertraline and presents with agitation. Vitals are T 39.0°C, HR 136, BP 166/92. Exam shows diaphoresis, tremor, hyperreflexia and inducible ankle clonus. Bowel sounds are increased. What is the most likely diagnosis?

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Correct answer: D — Serotonin syndrome

Serotonergic exposure with hyperreflexia and clonus is serotonin syndrome. Treatment is stopping agents, benzodiazepines, cooling and cyproheptadine in selected cases.

Reference: Canadian Poison Centre resources; toxicology guidance