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Severe hypercalcaemia of malignancy — SCE Acute Medicine MCQ

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HardAcute Renal and Metabolic EmergenciesSevere hypercalcaemia of malignancySCE Acute Medicine

A severely malnourished man begins enteral feeding after ten days of negligible intake. Thirty-six hours later he develops weakness, oedema and ventricular ectopy. Phosphate is 0.28 mmol/L, potassium 2.9 mmol/L and magnesium 0.48 mmol/L. What is the most appropriate response?

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Correct answer: CReduce feeding, give thiamine and replace all three electrolytes

The rapid fall in phosphate, potassium and magnesium with fluid retention after feeding is refeeding syndrome. Reduce caloric delivery, give thiamine, replace electrolytes promptly and monitor rhythm, fluid balance and biochemistry closely. Continuing full carbohydrate delivery increases insulin-driven intracellular shifts and can cause respiratory or cardiac failure.

Reference: https://www.nice.org.uk/guidance/cg32/chapter/Recommendations