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VO2max — MRCP Part 1 MCQ

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HardExercise PhysiologyVO2maxMRCP Part 1

A patient with primary adrenal insufficiency is febrile at 39.2°C with influenza but is drinking, not vomiting and haemodynamically stable. Their usual hydrocortisone is 10 mg on waking, 5 mg at noon and 5 mg at 17:00. What self-management advice is appropriate during the significant illness?

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Correct answer: DUse sick-day glucocorticoid dosing throughout the febrile illness

The best answer is “Use sick-day glucocorticoid dosing throughout the febrile illness”. Intercurrent significant physiological stress requires additional glucocorticoid according to the patient’s sick-day plan even when tablets can be retained. The emergency injection is used when oral medicine cannot be absorbed or severe deterioration occurs. Fludrocortisone does not replace cortisol stress cover, and omitting or leaving glucocorticoid unchanged risks adrenal crisis.

Reference: NICE NG243, Adrenal insufficiency: identification and management: https://www.nice.org.uk/guidance/ng243/chapter/Recommendations