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Autoimmune polyglandular syndrome type 1 — SCE Endocrinology MCQ

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HardNET/MENAutoimmune polyglandular syndrome type 1SCE Endocrinology

A 36-year-old woman has mucocutaneous candidiasis since childhood, hypocalcaemic seizures and new primary adrenal insufficiency. Anti-interferon antibodies are positive. What is the most likely diagnosis?

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Correct answer: E — Autoimmune polyglandular syndrome type 1

Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency indicate APS1, usually AIRE-related. APS2 more commonly involves Addison's disease with autoimmune thyroid disease or type 1 diabetes, without childhood candidiasis. Calcium and adrenal crises are key safety risks.

Reference: Society for Endocrinology Autoimmune Polyglandular Guidance