Primary male hypogonadism — SCE Endocrinology MCQ

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EasyReproductive EndocrinologyPrimary male hypogonadismSCE Endocrinology

A 53-year-old man has reduced libido, erectile dysfunction and fatigue. Morning testosterone is low on two samples; LH and FSH are high. Prolactin is normal. What is the most likely diagnosis?

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Correct answer: E — Primary hypogonadism

Low testosterone with raised gonadotrophins indicates primary testicular failure. Secondary hypogonadism would show low or inappropriately normal LH and FSH. Testosterone therapy decisions require symptom correlation and risk assessment.

Reference: Endocrine Society Testosterone Therapy Guideline