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Androgen-secreting adrenal tumour — SCE Endocrinology MCQ

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HardAdrenalAndrogen-secreting adrenal tumourSCE Endocrinology

A 27-year-old woman has amenorrhoea, hirsutism and serum testosterone 7.8 nmol/L. DHEAS is very high and pelvic ultrasound is normal. What is the most appropriate next investigation?

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Correct answer: E — Adrenal imaging after confirming androgen excess

Markedly elevated DHEAS suggests an adrenal source of androgen excess and should prompt urgent evaluation for adrenal tumour after confirmation. PCOS usually causes milder androgen elevation. Pelvic ultrasound cannot exclude adrenal pathology.

Reference: Endocrine Society Hirsutism Guideline