Pseudohypoparathyroidism — SCE Endocrinology MCQ

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HardCalcium/BonePseudohypoparathyroidismSCE Endocrinology

A 55-year-old man has hypocalcaemia, hyperphosphataemia and raised PTH. He has short fourth metacarpals and subcutaneous ossifications. What is the most likely diagnosis?

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Correct answer: D — Pseudohypoparathyroidism

End-organ resistance to PTH causes hypocalcaemia with raised PTH, and Albright hereditary osteodystrophy features support pseudohypoparathyroidism. True hypoparathyroidism has low PTH. The phenotype is an important clue in calcium disorders.

Reference: Endocrine Society Calcium Disorders Guidance