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Insulinoma — SCE Endocrinology MCQ

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HardNET/MENInsulinomaSCE Endocrinology

A patient with an SDHB-associated metastatic paraganglioma has negative iodine-123 MIBG imaging. Which functional imaging modality is most likely to demonstrate somatostatin-receptor-positive disease and guide radionuclide treatment assessment?

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Correct answer: C — Gallium-68 DOTATATE PET/CT

Many paragangliomas, particularly SDHx-related disease, express somatostatin receptors and are well demonstrated by gallium-68-labelled somatostatin-analogue PET/CT. The scan can also assess suitability for peptide-receptor radionuclide therapy. MIBG-negative disease will not be characterised by repeating unrelated thyroid or parathyroid nuclear studies.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/diabetes-and-other-endocrinal-nutritional-and-metabolic-conditions