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Glucagonoma — SCE Endocrinology MCQ

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ModerateNET/MENGlucagonomaSCE Endocrinology

A 57-year-old woman has diabetes, weight loss, angular cheilitis and a necrolytic migratory erythema. Glucagon is markedly raised and CT shows a pancreatic tail mass. What is the most likely diagnosis?

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Correct answer: A — Glucagonoma

Diabetes, weight loss and necrolytic migratory erythema are characteristic of glucagonoma. Insulinoma causes hypoglycaemia rather than diabetes. The rash is an important clinical clue to a pancreatic neuroendocrine tumour.

Reference: ENETS Neuroendocrine Tumour Guidance