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Drug-induced hyperprolactinaemia — SCE Endocrinology MCQ

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EasyPituitaryDrug-induced hyperprolactinaemiaSCE Endocrinology

A 46-year-old woman has low mood and weight gain. Prolactin is 1,600 mIU/L. She takes risperidone and has normal pituitary MRI. What is the most likely cause?

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Correct answer: B — Antipsychotic-induced hyperprolactinaemia

Dopamine antagonist antipsychotics commonly cause hyperprolactinaemia. A normal MRI and compatible drug history support a medication cause. Management should involve psychiatry because abrupt antipsychotic withdrawal can be harmful.

Reference: Endocrine Society Hyperprolactinaemia Guideline; BNF