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Acromegaly — SCE Endocrinology MCQ

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EasyPituitaryAcromegalySCE Endocrinology

A 52-year-old man has enlarged hands, headaches and sweating. IGF-1 is raised for age. Oral glucose tolerance test shows growth hormone 5.8 micrograms/L at baseline and 4.9 micrograms/L at 2 hours. What is the most likely diagnosis?

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Correct answer: A — Acromegaly

Raised IGF-1 with failure of GH suppression during OGTT confirms biochemical acromegaly. Prolactinoma may coexist or cause stalk effect but does not explain failed GH suppression. MRI pituitary is the next localisation test after biochemical confirmation.

Reference: Endocrine Society Acromegaly Guideline