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Premature ovarian insufficiency — SCE Endocrinology MCQ

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ModerateReproductive EndocrinologyPremature ovarian insufficiencySCE Endocrinology

A 38-year-old woman has 8 months of amenorrhoea, hot flushes and infertility. FSH is 72 IU/L on two occasions and oestradiol is low. Pregnancy test is negative. What is the most likely diagnosis?

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Correct answer: E — Premature ovarian insufficiency

Amenorrhoea with menopausal symptoms and repeatedly raised FSH before age 40 indicates premature ovarian insufficiency. PCOS usually has normal oestradiol and not markedly raised FSH. Management includes hormone replacement unless contraindicated and fertility counselling.

Reference: NICE NG23 Menopause; ESHRE POI Guideline