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MODY — SCE Endocrinology MCQ

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ModerateDiabetesMODYSCE Endocrinology

A 25-year-old man has diabetes diagnosed at age 18. He is slim, has stable fasting hyperglycaemia around 7.0 mmol/L and HbA1c 50 mmol/mol without ketosis. His mother and maternal grandfather developed mild diabetes before age 30. What is the most likely diagnosis?

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Correct answer: B — Glucokinase MODY

Stable mild fasting hyperglycaemia across generations is typical of glucokinase MODY. Type 1 diabetes would usually progress without insulin and ketosis-prone diabetes would not show lifelong mild stability. Recognition matters because pharmacological treatment is often not needed outside pregnancy-specific contexts.

Reference: Diabetes UK MODY Guidance; NICE NG17