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Central diabetes insipidus — SCE Endocrinology MCQ

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EasyPituitaryCentral diabetes insipidusSCE Endocrinology

A 36-year-old man has polyuria after trans-sphenoidal surgery. Urine output is 450 ml/hour, serum sodium is 151 mmol/L and urine osmolality is 95 mOsm/kg. What is the most likely diagnosis?

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Correct answer: A — Central diabetes insipidus

Postoperative polyuria with hypernatraemia and dilute urine indicates central diabetes insipidus. SIADH causes hyponatraemia and concentrated urine. Early recognition prevents severe dehydration after pituitary surgery.

Reference: Society for Endocrinology Pituitary Surgery Guidance