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Functional hypothalamic amenorrhoea — SCE Endocrinology MCQ

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ModerateReproductive EndocrinologyFunctional hypothalamic amenorrhoeaSCE Endocrinology

A 24-year-old woman has secondary amenorrhoea after weight loss and marathon training. BMI is 18 kg/m2, oestradiol is low, LH and FSH are low-normal, prolactin and TSH are normal. What is the most likely diagnosis?

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Correct answer: D — Functional hypothalamic amenorrhoea

Energy deficit and exercise with low oestradiol and low-normal gonadotrophins support functional hypothalamic amenorrhoea. Premature ovarian insufficiency would raise FSH. Bone health and nutritional rehabilitation are central management issues.

Reference: Endocrine Society Functional Hypothalamic Amenorrhoea Guideline