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VHL-associated phaeochromocytoma — SCE Endocrinology MCQ

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HardNET/MENVHL-associated phaeochromocytomaSCE Endocrinology

A 34-year-old woman with VHL has episodic headaches and hypertension. MRI abdomen shows bilateral adrenal lesions and plasma normetanephrine is raised. What is the most likely diagnosis?

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Correct answer: A — VHL-associated phaeochromocytoma

VHL is associated with phaeochromocytoma/paraganglioma among other tumours. Raised normetanephrine with adrenal lesions supports catecholamine-secreting disease. Genetic context influences screening for multifocal and extra-adrenal tumours.

Reference: Endocrine Society Phaeochromocytoma Guideline