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Knee osteoarthritis — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareKnee osteoarthritisUSMLE Step 3

A 64-year-old woman has gradual bilateral knee pain worse with activity and relieved by rest. Radiographs show medial joint-space narrowing and osteophytes. She has no inflammatory morning stiffness or systemic symptoms. BMI is 34 kg/m2. She wants to avoid surgery. Which of the following is the most appropriate at this time?

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Correct answer: B — Recommend exercise, weight loss, and topical NSAID therapy

First-line knee osteoarthritis management includes exercise, weight reduction when appropriate, and topical NSAIDs before invasive or opioid-based approaches.

Reference: American College of Rheumatology osteoarthritis guideline