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Rh alloimmunization prevention — USMLE Step 3 MCQ

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EasyOB/GYN (prenatal care, contraception, screening)Rh alloimmunization preventionUSMLE Step 3

A 26-year-old Rh-negative woman at 28 weeks' gestation has an uncomplicated pregnancy. Antibody screen is negative, partner Rh status is unknown, and fetal anatomy scan is normal. Which of the following is the most appropriate next step in management?

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Correct answer: C — Administer anti-D immune globulin now and again after delivery if the newborn is Rh-positive

Unsensitized Rh-negative pregnant patients receive anti-D immune globulin at 28 weeks and postpartum if indicated.

Reference: ACOG Rh D alloimmunization prevention guidance