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Heart failure with reduced ejection fraction — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)Heart failure with reduced ejection fractionUSMLE Step 3

A 66-year-old man with ischemic cardiomyopathy has dyspnea after walking two blocks. Ejection fraction is 32%. He takes carvedilol and furosemide. Blood pressure, potassium, and eGFR are acceptable. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: BStart sacubitril-valsartan after appropriate ACE inhibitor washout if needed

Guideline-directed therapy for HFrEF includes ARNI therapy when tolerated, in addition to beta-blocker and other foundational agents.

Reference: ACC/AHA/HFSA Heart Failure Guideline