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Migraine prophylaxis — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareMigraine prophylaxisUSMLE Step 3

A 36-year-old woman has migraine without aura 8 days per month despite appropriate acute therapy. She is not pregnant and has no asthma, depression, or kidney stones. Neurologic examination is normal. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: CStart preventive migraine therapy such as propranolol or topiramate after shared decision-making

Frequent migraines causing impairment warrant preventive therapy selected by comorbidities, pregnancy plans, and patient preference.

Reference: American Headache Society migraine prevention guidance