skip to main content

Statin-associated muscle symptoms — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

ModerateInternal Medicine (chronic management)Statin-associated muscle symptomsUSMLE Step 3

A 61-year-old man started high-intensity atorvastatin after myocardial infarction. Four weeks later he has bilateral thigh aches without weakness. Creatine kinase is mildly elevated at 210 U/L. He has no dark urine or renal dysfunction. Which of the following is the most likely explanation for this patient's findings?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Statin-associated muscle symptoms without rhabdomyolysis

Mild symmetric myalgias soon after statin initiation with minimal CK elevation are consistent with statin-associated muscle symptoms; severe CK elevation or renal injury would suggest rhabdomyolysis.

Reference: ACC/AHA cholesterol guideline