A 67-year-old man has progressive dyspnea, orthostatic dizziness, nephrotic-range proteinuria, macroglossia, and carpal tunnel symptoms.

Question

A 67-year-old man has progressive dyspnea, orthostatic dizziness, nephrotic-range proteinuria, macroglossia, and carpal tunnel symptoms. Echocardiography shows increased ventricular wall thickness with low voltage on ECG. Which of the following is the most likely diagnosis?

Accepted Answer

Systemic amyloidosis

Answer

Constrictive pericarditis

Answer

Hypertrophic obstructive cardiomyopathy

Answer

Chronic obstructive pulmonary disease

Answer

Sarcoid arthritis

Systemic amyloidosis — USMLE Step 3 MCQ

A 67-year-old man has progressive dyspnea, orthostatic dizziness, nephrotic-range proteinuria, macroglossia, and carpal tunnel symptoms. Echocardiography shows increased ventricular wall thickness with low voltage on ECG. Which of the following is the most likely diagnosis?