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SIADH — USMLE Step 3 MCQ

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ModerateInternal Medicine (chronic management)SIADHUSMLE Step 3

A 69-year-old man with small cell lung cancer has confusion. Sodium is 121 mEq/L, serum osmolality is low, urine osmolality is high, urine sodium is 58 mEq/L, and he appears euvolemic. Which of the following is the most likely diagnosis?

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Correct answer: CSyndrome of inappropriate antidiuretic hormone secretion

Euvolemic hypotonic hyponatremia with inappropriately concentrated urine and high urine sodium suggests SIADH.

Reference: Endocrine Society hyponatremia guidance